Dominic Dale, the world number 70, also reached Stage Two after topping his group with two wins and one draw.
Moises Caicedo put the hosts ahead with a 40th-minute strike at La Casa Blanca in Quito, more than 2,800m above sea level.
Internacional lead Group E, three points ahead of second-placed Gremio, who lost 2-0 at Universidad Catolica in Chilean capital Santiago.
Jota has agreed to a five-year deal with Liverpool and the move is likely to be completed as soon as the 23-year-old completes his medical check.
The changes mean that the weekend will open with Villarreal at home to Eibar, with Villarreal looking to improve on an opening day's performance that saw them held 1-1 at home by newly promoted Huesca.
SUZHOU, China, Sept. 15 (Xinhua) -- Shanghai SIPG claimed a 2-1 victory over Wuhan Zall, while Hebei China Fortune tied Beijing Guoan 3-3 in the 11th round of the Chinese Super League (CSL) here on Tuesday.
With this win, Al-Nassr replaced Al-Sadd SC at the top of Group D with seven points, while Sepahan remain in third place, two points off a knockout stage qualification spot ahead of matchday four's reverse fixture on Friday.
On Friday, Persepolis beat Al-Taawoun 1-0 in Group C of the 2020 AFC Champions League thanks to Resan's penalty.
In Chilean capital Santiago, Colo-Colo defeated Uruguay's Penarol 2-1 while Brazil's Santos were held to a goalless home draw by Paraguayan side Olimpia. Enditem
In the southern Brazilian city of Porto Alegre, Gabriel Boschilia scored in second-half stoppage time to hand Internacional a 4-3 home win over Colombia's America de Cali.
"Everyone will be desperate to beat Europe's top team," the 32-year-old Pole told Xinhua before the Bavarians' 2020/21 Bundesliga curtain-raiser against Schalke on Friday.