Wolves also claimed three points thanks to Pedro Neto's 56th minute goal at home against a Fulham side still looking for its first point since returning to the top-flight.
"It was a very even match, perhaps more difficult than the result showed," said Djokovic, who is seeking for an 18th Grand Slam title.
"We are in a very strange situation, after a lot of months without much tennis, especially for me, that I didn't play in America, I don't know if it's a positive thing or a negative thing," Nadal said when asked how important it was to keep the early-round matches short and sweet.
Atletico Madrid at home to Villarreal is Saturday's most attractive game, with Luis Suarez likely to start in the Wanda Metropolitano as Atletico looks to improve on its flat showing away to Huesca in midweek.
Al Nassr broke the deadlock with a penalty in the 35th minute before Abdi Mehdi Qara leveled for Persepolis just six minutes later.
Thomas will be a big loss for Atletico, but the club were able to compensate partly for his loss with Uruguayan midfielder Lucas Torreira arriving on loan from Arsenal with an option to make the deal permanent at the end of the season for 20 million euros.
The Spaniard, who is seeking his 13th title at Roland Garros, defeated Sinner 7-6 (7-4), 6-4, 6-1 to set up a rematch with Diego Schwartzman on Friday.
Following is the Argentina squad:
Next up for Halep is another 19-year-old youngster, Iga Swiatek of Poland, whom Halep defeated in the round of 16 here last year.
In the other action on Friday, women's third seed Elina Svitolina cruised past 27th-seeded Ekaterina Alexandrova 6-4, 7-5 to advance to the next round. Argentine qualifier Nadia Podoroska extended her stunning run on clay after the restart of the season, as the 23-year-old dispatched Anna Karolina Schmiedlova 6-3, 6-2 to become the first Argentinean women's player to reach the fourth round in Paris since 2011. Enditem
Kvitova went into the match quickly as she broke her Chinese opponent twice to surge to a 4-0 lead in the opening set, before serving for the set in the eighth game.